Thursday, April 11, 2013

Colangite/colangiohepatite bacteriana com ou sem colecistite em 4 cães / Bacterial cholangitis/cholangiohepatitis with or without concurrent cholecystitis in four dogs


Bacterial cholangitis/cholangiohepatitis with or without concurrent cholecystitis in four dogs

  1. E. J. O’Neill, 
  2. M. J. Day, 
  3. E. J. Hall, 
  4. D. J. Holden, 
  5. K. F. Murphy, 
  6. F. J. Barr, 
  7. G. R. Pearson
Article first published online: 25 MAY 2006
DOI: 10.1111/j.1748-5827.2006.00012.x
Journal of Small Animal Practice

Journal of Small Animal Practice

Volume 47Issue 6pages 325–335June 2006

ObjectivesTo evaluate the clinical, clinical pathology, diagnostic imaging, microbiological and pathological features of cholangitis/cholangiohepatitis in the dog.
MethodsThe study design was a retrospective review of cases of bacterial cholangitis/cholangiohepatitis presented to the University of Bristol during the period 1995 to 2000. The diagnosis was made based on hepatic histopathological findings and positive bile culture results.
ResultsFour dogs met the inclusion criteria. Common presenting signs included anorexia (n=4), jaundice (n=4), vomiting (n=4) and pyrexia (n=2). All four dogs had a leucocytosis or neutrophilia reported at some time in their history along with serum bilirubin elevation. In addition, serum alkaline phosphatase and alanine transaminase activity was increased in all of the dogs in which it was measured both before and at the time of referral. In general, the diagnostic imaging findings were non-specific. Organisms cultured from bile aspirates were Escherichia coli (n=3), Clostridium species (n=2) and a faecal Streptococcus species (n=1). Two cases resolved with medical treatment alone; two with concurrent cholecystitis required cholecystectomy. Following surgery, both of these cases showed a resolution of clinical signs.
Clinical SignificanceThis report highlights the fact that bacterial cholangitis/cholangiohepatitis with or without concurrent cholecystitis should be considered as a potential differential in dogs presenting with signs referable to biliary tract disease.

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